nature.com·May 13, 2026
The study identifies PTCHD1-AS, a long non-coding RNA, as linked to the development of autism spectrum disorder in humans, highlighting its role in striatal molecular and circuit-level dysregulation.
The study published in Nature reveals that PTCHD1-AS, a long non-coding RNA, plays a significant role in the molecular and circuit-level dysregulation within the striatum, contributing to the aetiology of autism spectrum disorder. This insight could guide future research in targeting RNA-based interventions for autism, potentially opening up new therapeutic avenues.