phys.org·Apr 13, 2026
A research team has developed an improved CRISPR gene-editing system using a naturally occurring enzyme, Al3Cas12f, which can be effectively delivered inside the human body via adeno-associated virus vectors, significantly enhancing gene-editing performance in human cells and advancing its clinical applications.
The discovery of the enhanced CRISPR system using the Al3Cas12f enzyme, which fits into adeno-associated virus vectors, represents a significant advancement for targeted gene therapy delivery. This breakthrough not only enhances gene-editing performance in human cells but also moves us closer to broader clinical applications, indicating potential for future Nobel Prize-level recognition in gene editing and therapeutic fields.